The Extracellular Matrix

Faculty: Gregory Shultz, PhD, Richard A. Clark, MD, Eliot N. Mostow, MD, MPH

Description:Dermal extracellular matrix dysfunction is one of the factors associated with chronic non-healing wounds. Dr. Schultz will discuss mechanisms by which the dermis is broken and alterations in inflammatory cytokines and proteases contribute to a diseased dermal matrix. Dr. Clark will discuss bench approaches to re-capitulate the dermal matrix to create novel matrices that might be suitable to improve repair. Dr. Mostow will provide insight into the clinical use of matrices to improve outcomes and healing refractory ulcers.

Credits: 1.5